Antibiotic adjuvants: a versatile approach to combat antibiotic resistance
The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …
Combination approaches to combat multidrug-resistant bacteria
RJ Worthington, C Melander - Trends in biotechnology, 2013 - cell.com
The increasing prevalence of infections caused by multidrug-resistant bacteria is a global
health problem that has been exacerbated by the dearth of novel classes of antibiotics …
health problem that has been exacerbated by the dearth of novel classes of antibiotics …
Antibiotic adjuvants: diverse strategies for controlling drug‐resistant pathogens
The growing number of bacterial pathogens that are resistant to numerous antibiotics is a
cause for concern around the globe. There have been no new broad‐spectrum antibiotics …
cause for concern around the globe. There have been no new broad‐spectrum antibiotics …
Antibacterial activities of sulfonyl or sulfonamide containing heterocyclic derivatives and its structure-activity relationships (SAR) studies: A critical review
The rise of drug-resistance has made the deserted clinical requirement to improve of new
classes of antibiotics agents. The development of antibacterial agents with the novel method …
classes of antibiotics agents. The development of antibacterial agents with the novel method …
Efflux pump inhibitors of clinically relevant multidrug resistant bacteria
A Lamut, L Peterlin Mašič, D Kikelj… - Medicinal Research …, 2019 - Wiley Online Library
Bacterial infections are an increasingly serious issue worldwide. The inability of existing
therapies to treat multidrug‐resistant pathogens has been recognized as an important …
therapies to treat multidrug‐resistant pathogens has been recognized as an important …
Efflux pump mediated antimicrobial resistance by staphylococci in health-related environments: challenges and the quest for inhibition
A Dashtbani-Roozbehani, MH Brown - Antibiotics, 2021 - mdpi.com
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …
health threat worldwide due to significant morbidity and mortality resulting from their …
Modulation of bacterial multidrug resistance efflux pumps of the major facilitator superfamily
S Kumar, MM Mukherjee… - International journal of …, 2013 - Wiley Online Library
Bacterial infections pose a serious public health concern, especially when an infectious
disease has a multidrug resistant causative agent. Such multidrug resistant bacteria can …
disease has a multidrug resistant causative agent. Such multidrug resistant bacteria can …
Pharmaceutical approaches to target antibiotic resistance mechanisms
D Schillaci, V Spanò, B Parrino… - Journal of medicinal …, 2017 - ACS Publications
There is urgent need for new therapeutic strategies to fight the global threat of antibiotic
resistance. The focus of this Perspective is on chemical agents that target the most common …
resistance. The focus of this Perspective is on chemical agents that target the most common …
The intrinsic resistome of bacterial pathogens
J Olivares, A Bernardini, G Garcia-Leon… - Frontiers in …, 2013 - frontiersin.org
Intrinsically resistant bacteria have emerged as a relevant health problem in the last years.
Those bacterial species, several of them with an environmental origin, present naturally low …
Those bacterial species, several of them with an environmental origin, present naturally low …
Functional and structural roles of the major facilitator superfamily bacterial multidrug efflux pumps
Pathogenic microorganisms that are multidrug-resistant can pose severe clinical and public
health concerns. In particular, bacterial multidrug efflux transporters of the major facilitator …
health concerns. In particular, bacterial multidrug efflux transporters of the major facilitator …