This review examines the large body of toxicological and epidemiological information on
human exposures to chlorpyrifos, with an emphasis on the controversial potential for …

In vitro models may be useful for the rapid toxicological screening of large numbers of
chemicals for their potential to produce toxicity. Such screening could facilitate prioritization …

Identification of chemicals that pose a hazard to the developing nervous system is the first
step in reducing human exposure and preventing health risks to infants and children. In …

Evidence that children are widely exposed to organophosphorus pesticides (OPs) and that
OPs cause developmental neurotoxicity in animal models raises significant concerns about …

Axonal morphology is a critical determinant of neuronal connectivity, and perturbation of the
rate or extent of axonal growth during development has been linked to neurobehavioral …

Previous studies suggest that low doses of the organophosphate insecticide chlorpyrifos
(CPF) disrupt brain development and cognitive function by mechanisms that do not involve …

A primary role of acetylcholinesterase (AChE) is regulation of cholinergic neurotransmission
by hydrolysis of synaptic acetylcholine. In the developing nervous system, however, AChE …

Organophosphate biocide chlorpyrifos (CPF) is involved with breast cancer. However, the
mechanisms remain unknown. CPF increases cell division in MCF-7 cells, by estrogen …

The developmental neurotoxicity of the organophosphate pesticide chlorpyrifos (CPF) is
thought to involve both neurons and glia, thus producing a prolonged window of …

Monocrotophos (MCP) is a commonly used organophosphorus (OP) pesticide. We studied
apoptotic changes in PC12 cells exposed to MCP. A significant induction in reactive oxygen …