Computational models in cardiology
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
The openCARP simulation environment for cardiac electrophysiology
Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …
long and rich tradition of computational modeling. Nevertheless, no community standard for …
[HTML][HTML] Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …
mechanisms, are usually performed with channels expressed in non myocytes, or with non …
Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation
Background—Electrical, structural, and Ca2+-handling remodeling contribute to the
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …
Artificial intelligence in the diagnosis and management of arrhythmias
VD Nagarajan, SL Lee, JL Robertus… - European heart …, 2021 - academic.oup.com
The field of cardiac electrophysiology (EP) had adopted simple artificial intelligence (AI)
methodologies for decades. Recent renewed interest in deep learning techniques has …
methodologies for decades. Recent renewed interest in deep learning techniques has …
Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation
Rationale: Understanding atrial fibrillation (AF) requires integrated understanding of ionic
currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited …
currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited …
Computational models of atrial fibrillation: Achievements, challenges, and perspectives for improving clinical care
Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …
[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
[HTML][HTML] Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies
Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …