Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …

Macrophage differentiation and polarization are essential players in the success of the
wound-healing process. Acute simple wounds progress from inflammation to proliferation …

The facilitative GLUT1 and GLUT3 hexose transporters are expressed abundantly in
macrophages, but whether they have distinct functions remains unclear. We confirmed that …

Ischemic stroke is the second leading cause of death worldwide with limited medications
and neuroinflammation was recognized as a critical player in the progression of stroke, but …

Aims Mitochondrial perturbations are the major culprit of the inflammatory response during
the initial phase of cerebral ischemia. The present study explored the neuroprotective effect …

Adipose-derived stem cells (ADSCs) show potential in skin regeneration research. A
previous study reported the failure of full-thickness skin self-repair in an injury area …

Abstract Sirtuins (SIRT1-SIRT7), as a family of NAD+-dependent protein modifying enzymes,
have various catalytic functions, such as deacetylases, dealkalylases, and deribonucleases …

Rationale: Diabetes exacerbates the prevalence and severity of periodontitis, leading to
severe periodontal destruction and ultimately tooth loss. Delayed resolution of inflammation …

Purpose The failure in timely healing of wounds is a central feature in chronic wounds that
leads to physiological, psychological and economic burdens. Macrophages have been …

Background Silent information regulator 6 (SIRT6) is a mammalian homolog of the
nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Prior …