Cisplatin is currently one of the most widely-used chemotherapeutic agents against various
malignancies. Its clinical application is limited, however, by inherent renal and cardiac …

Drug‐induced toxicity is a key issue for public health because some side effects can be
severe and life‐threatening. These adverse effects can also be a major concern for the …

The liver is one of the pivotal organs in the human body and is fundamentally responsible for
detoxification and metabolism. Various disorders such as non-alcoholic fatty liver disease …

ETHNOPHARMACOLOGICAL RELEVANCE: The increasing use of traditional herbal
medicines around the world requires more scientific evidence for their putative …

A host of novel renal biomarkers have been developed over the past few decades which
have enhanced monitoring of renal disease and drug-induced kidney injury in both …

In an unbiased approach to biomarker discovery, we applied a highly multiplexed proteomic
technology (SOMAscan, SomaLogic, Inc, Boulder, CO) to understand changes in proteins …

This review investigates optical sensor platforms for protein multiplexing, the ability to
analyze multiple analytes simultaneously. Multiplexing is becoming increasingly important …

Investigative toxicology describes the de-risking and mechanistic elucidation of toxicities,
supporting early safety decisions in the pharmaceutical industry. Recently, investigative …

The non-animal in vitro test methods, especially for assessment of kidney toxicity, have
become invaluable tools due to the target organ-selective nature of many nephrotoxic …

Large inter-individual variability in drug response and toxicity, as well as in drug
concentrations after application of the same dosage, can be of genetic, physiological …