Calcium-release channels: structure and function of IP3 receptors and ryanodine receptors
KA Woll, F Van Petegem - Physiological Reviews, 2022 - journals.physiology.org
Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …
Cardiac transverse tubules in physiology and heart failure
KM Dibb, WE Louch, AW Trafford - Annual review of physiology, 2022 - annualreviews.org
In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …
but also a network of membrane invaginations called transverse (t-) tubules. These …
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we
previously showed that 'dispersion'of RyR clusters disrupts Ca 2+ homeostasis during heart …
previously showed that 'dispersion'of RyR clusters disrupts Ca 2+ homeostasis during heart …
Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling
L Guarina, AN Moghbel… - Journal of General …, 2022 - rupress.org
Each heartbeat begins with the generation of an action potential in pacemaking cells in the
sinoatrial node. This signal triggers contraction of cardiac muscle through a process termed …
sinoatrial node. This signal triggers contraction of cardiac muscle through a process termed …
Nanoscale organization, regulation, and dynamic reorganization of cardiac calcium channels
RE Dixon - Frontiers in physiology, 2022 - frontiersin.org
The architectural specializations and targeted delivery pathways of cardiomyocytes ensure
that L-type Ca2+ channels (CaV1. 2) are concentrated on the t-tubule sarcolemma within …
that L-type Ca2+ channels (CaV1. 2) are concentrated on the t-tubule sarcolemma within …
Cardiac multiscale bioimaging: from nano-through micro-to mesoscales
Cardiac multiscale bioimaging is an emerging field that aims to provide a comprehensive
understanding of the heart and its functions at various levels, from the molecular to the entire …
understanding of the heart and its functions at various levels, from the molecular to the entire …
Diversity of cells and signals in the cardiovascular system
This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …
Symposium on Systems Approach to Understanding Cardiovascular Disease and …
Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Ca2+ sparks constitute the fundamental units of Ca2+ release in cardiomyocytes. Here we
investigate how ryanodine receptors (RyRs) collectively generate these events by …
investigate how ryanodine receptors (RyRs) collectively generate these events by …
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol
DRL Scriven, AB Johnsen, P Asghari… - Journal of General …, 2023 - rupress.org
Earlier work has shown that ventricular ryanodine receptors (RyR2) within a cluster
rearrange on phosphorylation as well as with a number of other stimuli. Using dSTORM, we …
rearrange on phosphorylation as well as with a number of other stimuli. Using dSTORM, we …
Three-dimensional visualization of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads
TMD Sheard, ME Hurley, AJ Smith… - … of the Royal …, 2022 - royalsocietypublishing.org
Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular
machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical …
machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical …