Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis

P Rodríguez-Morales, RA Franklin - Trends in Immunology, 2023 - cell.com
Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

Innate immunity and interferon in SARS-CoV-2 infection outcome

R Savan, M Gale - Immunity, 2023 - cell.com
Innate immunity and the actions of type I and III interferons (IFNs) are essential for protection
from SARS-CoV-2 and COVID-19. Each is induced in response to infection and serves to …

Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury

C Ruscitti, J Abinet, P Maréchal, M Meunier… - Science …, 2024 - science.org
The lung is constantly exposed to airborne pathogens and particles that can cause alveolar
damage. Hence, appropriate repair responses are essential for gas exchange and life. Here …

Bacteriophage T4 as a Protein-Based, Adjuvant-and Needle-Free, Mucosal Pandemic Vaccine Design Platform

J Zhu, P Tao, AK Chopra, VB Rao - Annual Review of Virology, 2024 - annualreviews.org
The COVID-19 pandemic has transformed vaccinology. Rapid deployment of mRNA
vaccines has saved countless lives. However, these platforms have inherent limitations …

Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae after acute COVID-19

C Li, W Qian, X Wei, H Narasimhan, Y Wu… - Science translational …, 2024 - science.org
Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection (PASC) represent an urgent public health challenge and are estimated to affect …

Inhalation drug delivery in combating pulmonary infections: Advances and challenges

P Kumbhar, J Kaur, G De Rubis, KR Paudel… - Journal of Drug Delivery …, 2023 - Elsevier
Pulmonary infections (PIs) are contributing as a significant cause of mortality across the
world. The clinical applications of a variety of therapeutics approved for PIs have been …

[HTML][HTML] Pulmonary delivery of silver nanoparticles prevents influenza infection by recruiting and activating lymphoid cells

L Martín-Faivre, L Prince, C Cornu, B Villeret… - Biomaterials, 2025 - Elsevier
Silver nanoparticles (AgNPs) are a potential antiviral agent due to their ability to disrupt the
viral particle or alter the virus metabolism inside the host cell. In vitro, AgNPs exhibit antiviral …

An aberrant immune–epithelial progenitor niche drives viral lung sequelae

H Narasimhan, IS Cheon, W Qian, SS Hu, T Parimon… - Nature, 2024 - nature.com
The long-term physiological consequences of respiratory viral infections, particularly in the
aftermath of the COVID-19 pandemic—termed post-acute sequelae of SARS-CoV-2 (PASC) …

Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report

SC Auld, A Sheshadri, J Alexander-Brett… - Annals of the …, 2024 - atsjournals.org
Continued improvements in the treatment of pulmonary infections have paradoxically
resulted in a growing challenge of individuals with postinfectious pulmonary complications …

Regional specialization within the mammalian respiratory immune system

DPH van Konijnenburg, PA Nigrovic, I Zanoni - Trends in Immunology, 2024 - cell.com
The respiratory tract is exposed to infection from inhaled pathogens, including viruses,
bacteria, and fungi. So far, a comprehensive assessment that integrates common and …