Signal transducer and activator of transcription 5 (STAT5) is an attractive therapeutic target,
but successful targeting of STAT5 has proved to be difficult. Here we report the development …

The development of biologics targeting various aspects of type 2 inflammation for the
treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) will provide clinicians with …

Abstract Globally, a small proportion (5–12%) of asthma patients are estimated to have
severe disease. However, severe asthma accounts for disproportionately high healthcare …

STAT5 is an attractive therapeutic target for human cancers. We report herein the discovery
of a potent and selective STAT5 degrader with strong antitumor activity in vivo. We first …

Aging is the single largest risk factor for many debilitating conditions, including heart
diseases, stroke, cancer, diabetes, and neurodegenerative disorders. Although far from …

Signal transducer and activator of transcription (STAT)-6 is a transcription factor central to
pro-allergic immune responses, although the function of human STAT6 at the whole …

Unified airway disease, including concurrent asthma and chronic rhinosinusitis (CRS), is a
common, but poorly understood disorder with no curative treatment options. To establish a …

The most common form of polycystic kidney disease (PKD) in humans is caused by
mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many identified or …

A series of landmark studies have provided conclusive evidence that the early
administration of food allergens dramatically prevents the emergence of food allergy. One of …

Zgodnie z definicją przyjętą przez Europejską Agencję Leków (European Medicines Agency–
EMA) lekami biologicznymi nazywamy te leki, które zostały wytworzone przez żywe …