An outstanding characteristic of gliomas is their infiltration into brain parenchyma, a property
that impairs complete surgical resection; consequently, these tumors might recur, resulting in …

Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …

The chemotherapy of glioblastoma is severely hindered by the immunosuppressive tumor
microenvironment, especially the tumor growth factor β (TGF‐β), an immunosuppressive …

Abstract Background Recurrence of Glioblastoma multiforme (GBM) seems to be the rule
despite combination therapies. Cell invasion and cell proliferation are major reasons for …

Chronic exposure to fluoride has been associated with the development of skeletal fluorosis.
Limited reports are available on fluoride induced histone modification. However, the role of …

He, we show that combined use of the EZH2 inhibitor GSK126 and the CDK4/6 inhibitor
abemaciclib synergistically enhances antitumoral effects in preclinical GBM models. Dual …

Previous studies suggest that the reduction of SMAD3 (mothers against decapentaplegic
homolog 3) has a great impact on tumor development, but its exact pathological function …

Objective The present study aims to explore the correlation of the transforming growth factor
β (TGF-β), drosophila mothers against decapentaplegic protein gene (SMAD) 2/3/4, and …

The incidence of diabetes mellitus has become a major public health concern due to lifestyle
alterations. Moreover, the complications associated with diabetes mellitus deeply influence …

Purpose: To investigate the influence of bleomycin (BLM) on the proliferation and apoptosis
of brain glioma cells through transforming growth factor-β (TGF-β)/Smads signaling pathway …