Whole cell biocatalysts: essential workers from nature to the industry
CCCR de Carvalho - Microbial Biotechnology, 2017 - Wiley Online Library
Microorganisms have been exposed to a myriad of substrates and environmental conditions
throughout evolution resulting in countless metabolites and enzymatic activities. Although …
throughout evolution resulting in countless metabolites and enzymatic activities. Although …
Life cycle assessment of multi-step rufinamide synthesis–from isolated reactions in batch to continuous microreactor networks
D Ott, S Borukhova, V Hessel - Green Chemistry, 2016 - pubs.rsc.org
Rufinamide is an antiepileptic drug to treat Lennox–Gastaut syndrome, in combination with
other medications. Rufinamide is one of the best-selling 5-membered ring heterocyclic …
other medications. Rufinamide is one of the best-selling 5-membered ring heterocyclic …
An improved whole-cell biosensor for the discovery of lignin-transforming enzymes in functional metagenomic screens
The discovery and utilization of biocatalysts that selectively valorize lignocellulose is critical
to the profitability of next-generation biorefineries. Here, we report the development of a …
to the profitability of next-generation biorefineries. Here, we report the development of a …
E. coli metabolic engineering for gram scale production of a plant-based anti-inflammatory agent
MK Ahmadi, L Fang, N Moscatello, BA Pfeifer - Metabolic engineering, 2016 - Elsevier
In this report, the heterologous production of salicylate (SA) is the basis for metabolic
extension to salicylate 2-O-β-d-glucoside (SAG), a natural product implicated in plant-based …
extension to salicylate 2-O-β-d-glucoside (SAG), a natural product implicated in plant-based …
Functional genomics for the oleaginous yeast Yarrowia lipolytica
K Patterson, J Yu, J Landberg, I Chang, F Shavarebi… - Metabolic …, 2018 - Elsevier
Oleaginous yeasts are valuable systems for biosustainable production of hydrocarbon-
based chemicals. Yarrowia lipolytica is one of the best characterized of these yeast with …
based chemicals. Yarrowia lipolytica is one of the best characterized of these yeast with …
Bioproduction of benzylamine from renewable feedstocks via a nine‐step artificial enzyme cascade and engineered metabolic pathways
Production of chemicals from renewable feedstocks has been an important task for
sustainable chemical industry. Although microbial fermentation has been widely employed …
sustainable chemical industry. Although microbial fermentation has been widely employed …
Process modeling, simulation, and technoeconomic evaluation of separation solvents for the continuous pharmaceutical manufacturing (CPM) of diphenhydramine
S Diab, DI Gerogiorgis - Organic Process Research & …, 2017 - ACS Publications
Continuous Pharmaceutical Manufacturing (CPM) has been shown to provide significant
process benefits, including cost savings and increased material efficiencies, over the …
process benefits, including cost savings and increased material efficiencies, over the …
Metagenomic discovery of a novel transaminase for valorization of monoaromatic compounds
The profitability of next-generation biorefineries is acutely contingent on the discovery and
utilization of biocatalysts that can valorize lignin. To this end, the metabolic catalogues of …
utilization of biocatalysts that can valorize lignin. To this end, the metabolic catalogues of …
Metabolomics for industrial fermentation
Metabolomics is essential to understand the metabolism and identify engineering targets to
improve the performances of strains and bioprocesses. Although numerous metabolomics …
improve the performances of strains and bioprocesses. Although numerous metabolomics …
Continuous manufacturing: the future in pharmaceutical solid dosage form manufacturing
As rising costs outpace new drug development, the pharmaceutical industry has come under
intense pressure to improve the efficiency of its manufacturing processes. Continuous …
intense pressure to improve the efficiency of its manufacturing processes. Continuous …