Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell
death. Although these cell death programmes can protect the host against microbial …

Caspases are an evolutionary conserved family of cysteine proteases that are centrally
involved in cell death and inflammation responses. A wealth of foundational insight into the …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

The most common cause of death in the intensive care unit (ICU) is the development of
multiorgan dysfunction syndrome (MODS). Besides life-supporting treatments, no cure …

Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of
proinflammatory cytokines. Recent studies revealed that apoptotic caspase-8 directly …

Initially described as an interferon (IFN) γ‐inducing factor, interleukin (IL)‐18 is indeed
involved in Th1 and NK cell activation, but also in Th2, IL‐17‐producing γδ T cells and …

Sepsis is a life-threatening condition caused by pathogen infection and associated with
pyroptosis. Pyroptosis occurs upon activation of proinflammatory caspases and their …

Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Pyroptosis, a form of programmed cell death, has garnered increasing attention as it relates
to innate immunity and diseases. The discovery of caspase-1/3/4/5/8/11 function in sensing …