Pioneering research studies, beginning with those using Drosophila, have identified several
molecular and cellular mechanisms for active forgetting. The currently known mechanisms …

Synapses are specialized cell–cell contacts that mediate communication between neurons.
Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich …

The role of the hippocampus in recognition memory is controversial. Recognition memory
judgments may be made using different types of information, including object familiarity, an …

Major depressive disorder is associated with abnormalities in the brain and the immune
system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms …

High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

Memory impairments are associated with many brain disorders such as autism, Alzheimer's
disease, and depression. Forming memories involves modifications of synaptic transmission …

Repeated cocaine administration increases the dendritic arborization of nucleus accumbens
neurons, but the underlying signaling events remain unknown. Here we show that repeated …

The brain has a remarkable but underappreciated capacity to limit memory formation and
expression. The term" memory suppressor gene" was coined in 1998 as an attempt to …

Differentiated status, low regenerative capacity and complex signaling make neuronal
tissues highly susceptible to translating an imbalance in cell homeostasis into cell death …