Early-life glucocorticoids programme behaviour and metabolism in adulthood in zebrafish

KS Wilson, CS Tucker, EAS Al-Dujaili… - Journal of …, 2016 - joe.bioscientifica.com
Glucocorticoids (GCs) in utero influence embryonic development with consequent
programmed effects on adult physiology and pathophysiology and altered susceptibility to …

Dexamethasone induces apoptosis in the developing rat amygdala in an age-, region-, and sex-specific manner

DG Zuloaga, DL Carbone, R Hiroi, DL Chong… - Neuroscience, 2011 - Elsevier
Exposure to glucocorticoids (GCs) in early development can lead to long-term changes in
brain function and behavior, although little is known about the underlying neural …

Manual versus automated rodent behavioral assessment: comparing efficacy and ease of Bederson and Garcia neurological deficit scores to an open field video …

FA Desland, A Afzal, Z Warraich… - Journal of central …, 2014 - journals.sagepub.com
Animal models of stroke have been crucial in advancing our understanding of the
pathophysiology of cerebral ischemia. Currently, the standards for determining neurological …

Neonatal dexamethasone exposure down-regulates GnRH expression through the GnIH pathway in female mice

T Soga, SL Dalpatadu, DW Wong, IS Parhar - Neuroscience, 2012 - Elsevier
Synthetic glucocorticoid (dexamethasone; DEX) treatment during the neonatal stage is
known to affect reproductive activity. However, it is still unknown whether neonatal stress …

Neonatal dexamethasone treatment for chronic lung disease of prematurity alters the hypothalamus-pituitary-adrenal axis and immune system activity at school age

R Karemaker, A Kavelaars, M Ter Wolbeek… - …, 2008 - publications.aap.org
OBJECTIVE. To compare long-term effects of neonatal treatment with dexamethasone or
hydrocortisone for chronic lung disease of prematurity on the hypothalamus-pituitary …

Role of the NMDA receptor in cognitive deficits, anxiety and depressive-like behavior in juvenile and adult mice after neonatal dexamethasone exposure

SX Li, Y Fujita, JC Zhang, Q Ren, T Ishima, J Wu… - Neurobiology of …, 2014 - Elsevier
Postnatal dexamethasone (DEX) therapy has been used to treat or prevent chronic lung
disease after premature births. However, there are many reports of long-term negative …

Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose …

ML Kreider, CA Tate, MM Cousins, CA Oliver… - …, 2006 - nature.com
Glucocorticoids administered to prevent respiratory distress in preterm infants are
associated with neurodevelopmental disorders. To evaluate the long-term effects on …

Lower birth weight and attenuated adrenocortical response to ACTH in offspring from sows that orally received cortisol during gestation

G Kranendonk, H Hopster, M Fillerup, ED Ekkel… - Domestic Animal …, 2006 - Elsevier
Prenatal stress is known to affect several offspring characteristics, but its effects depend
among other factors on the period of gestation in which it is applied. In the present study …

Neonatal glucocorticoid treatment: Long-term effects on the hypothalamus–pituitary–adrenal axis, immune system, and problem behavior in 14–17 year old …

M Ter Wolbeek, A Kavelaars, WB de Vries… - Brain, behavior, and …, 2015 - Elsevier
Neonatal glucocorticoid (GC) treatment is used to prevent bronchopulmonary dysplasia
(BPD) in prematurely born babies. In the 1990s, treatment regimens with relatively high …

Reduced life expectancy in rats after neonatal dexamethasone treatment

PJGH Kamphuis, WB De Vries, JM Bakker… - Pediatric …, 2007 - nature.com
The glucocorticoid dexamethasone (Dex) is widely used in preterm infants for the prevention
of chronic lung disease. However, major concern has arisen about the long-term sequelae …