[HTML][HTML] In silico vaccine design: A tutorial in immunoinformatics

DD Martinelli - Healthcare Analytics, 2022 - Elsevier
Immunoinformatics, as a discipline, concerns the application of computational systems to
study the immune system. Recently, the principles of reverse vaccinology have united with …

Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus

AO Fadaka, NRS Sibuyi, DR Martin, M Goboza… - Scientific reports, 2021 - nature.com
Dengue poses a global health threat, which will persist without therapeutic intervention.
Immunity induced by exposure to one serotype does not confer long-term protection against …

Clostridium septicum: A review in the light of alpha-toxin and development of vaccines

MLF Alves, MRA Ferreira, RA Donassolo… - Vaccine, 2021 - Elsevier
Clostridium septicum (CS) is a pathogen that can cause the death of animals in livestock
worldwide through its main virulence factor, alpha-toxin (ATX). The aspects involved in …

Design of a novel multi-epitope vaccine candidate against hepatitis C virus using structural and nonstructural proteins: An immunoinformatics approach

E Behmard, HT Abdulabbas, S Abdalkareem Jasim… - PLoS …, 2022 - journals.plos.org
Hepatitis C virus (HCV) infects the liver and causes chronic infection. Several mutations in
the viral genome have been associated with drug resistance development. Currently, there …

Integrated core proteomics, subtractive proteomics, and immunoinformatics investigation to unveil a potential multi-epitope vaccine against schistosomiasis

A Rehman, S Ahmad, F Shahid, A Albutti… - Vaccines, 2021 - mdpi.com
Schistosomiasis is a parasitic infection that causes considerable morbidity and mortality in
the world. Infections of parasitic blood flukes, known as schistosomes, cause the disease …

Multi-epitope vaccine against SARS-CoV-2 applying immunoinformatics and molecular dynamics simulation approaches

Jyotisha, S Singh, IA Qureshi - Journal of Biomolecular Structure …, 2022 - Taylor & Francis
Abstract COVID-19, caused by SARS-CoV-2, is severe respiratory illnesses leading to
millions of deaths worldwide in very short span. The high case fatality rate and the lack of …

Combining Phage Display Technology with In Silico-Designed Epitope Vaccine to Elicit Robust Antibody Responses against Emerging Pathogen Tilapia Lake Virus

YM Gong, XF Wei, YY Zheng, Y Li, Q Yu, PF Li… - Journal of …, 2023 - Am Soc Microbiol
Antigen epitope identification is a critical step in the vaccine development process and is a
momentous cornerstone for the development of safe and efficient epitope vaccines. In …

An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani …

MAA Khan, JQ Ami, K Faisal, R Chowdhury, P Ghosh… - Parasites & vectors, 2020 - Springer
Background Visceral leishmaniasis (VL) caused by dimorphic Leishmania species is a
parasitic disease with high socioeconomic burden in endemic areas worldwide. Sustaining …

Computational Modeling, High-Level Soluble Expression and In Vitro Cytotoxicity Assessment of Recombinant Pseudomonas aeruginosa Azurin: A Promising Anti …

S Aslam, HM Rehman, MZ Sarwar, A Ahmad, N Ahmed… - Pharmaceutics, 2023 - mdpi.com
Azurin is a natural protein produced by Pseudomonas aeruginosa that exhibits potential anti-
tumor, anti-HIV, and anti-parasitic properties. The current study aimed to investigate the …

[HTML][HTML] Proteome based mapping and reverse vaccinology techniques to contrive multi-epitope based subunit vaccine (MEBSV) against Streptococcus pyogenes

S Aslam, UA Ashfaq, T Zia, N Aslam, F Alrumaihi… - Infection, Genetics and …, 2022 - Elsevier
Streptococcus pyogenes is a root cause of human infection like pharyngitis, tonsillitis, scarlet
fever, impetigo, and respiratory tract infections. About 11 million individuals in the US suffer …