Insulin stimulates glucose uptake into adipocytes via mTORC2/AKT signaling and GLUT4
translocation and directs glucose carbons into glycolysis, glycerol for TAG synthesis, and de …

Skeletal muscles mainly contribute to the emergence of insulin resistance, impaired glucose
tolerance and the development of type 2 diabetes. Molecular mechanisms that regulate …

Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving
multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic …

Impaired glucose tolerance associated with obesity causes postprandial hyperglycemia and
can lead to type 2 diabetes. To study the differences in liver metabolism in healthy and …

The decision of whether cells are activated or not is controlled through dynamic intracellular
molecular networks. However, the low population of cells during the transition state of …

Cells change their metabolism in response to internal and external conditions by regulating
the trans-omic network, which is a global biochemical network with multiple omic layers …

Glucose homeostasis is maintained by modulation of metabolic flux. Enzymes and
metabolites regulate the involved metabolic pathways. Dysregulation of glucose …

An effective combination of multi-omic datasets can enhance our understanding of complex
biological phenomena. To build a context-dependent network with multiple omic layers, ie, a …

Insulin regulates various cellular metabolic processes by activating specific isoforms of the
Akt family of kinases. Here, we elucidated metabolic pathways that are regulated in an Akt2 …

Adipocyte differentiation is a sequential process involving increased expression of
peroxisome proliferator-activated receptor gamma (PPARγ), adipocyte-specific gene …