Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish
ND Lawson, SA Wolfe - Developmental cell, 2011 - cell.com
The development of facile forward and reverse genetic approaches has propelled the
deconvolution of gene function in biology. While the origins of these techniques reside in the …
deconvolution of gene function in biology. While the origins of these techniques reside in the …
Retroviral insertional mutagenesis: past, present and future
AG Uren, J Kool, A Berns, M Van Lohuizen - Oncogene, 2005 - nature.com
Retroviral insertion mutagenesis screens in mice are powerful tools for efficient identification
of oncogenic mutations in an in vivo setting. Many oncogenes identified in these screens …
of oncogenic mutations in an in vivo setting. Many oncogenes identified in these screens …
Gene transfer into genomes of human cells by the sleeping beauty transposon system
Abstract The Sleeping Beauty (SB) transposon system, derived from teleost fish sequences,
is extremely effective at delivering DNA to vertebrate genomes, including those of humans …
is extremely effective at delivering DNA to vertebrate genomes, including those of humans …
High-resolution genome-wide mapping of transposon integration in mammals
SR Yant, X Wu, Y Huang, B Garrison… - … and cellular biology, 2005 - Am Soc Microbiol
Abstract The Sleeping Beauty (SB) transposon is an emerging tool for transgenesis, gene
discovery, and therapeutic gene delivery in mammals. Here we studied 1,336 SB insertions …
discovery, and therapeutic gene delivery in mammals. Here we studied 1,336 SB insertions …
In vivo protein trapping produces a functional expression codex of the vertebrate proteome
We describe a conditional in vivo protein-trap mutagenesis system that reveals
spatiotemporal protein expression dynamics and can be used to assess gene function in the …
spatiotemporal protein expression dynamics and can be used to assess gene function in the …
Transposons as tools for functional genomics in vertebrate models
Genetic tools and mutagenesis strategies based on transposable elements are currently
under development with a vision to link primary DNA sequence information to gene …
under development with a vision to link primary DNA sequence information to gene …
Nicotine response genetics in the zebrafish
AM Petzold, D Balciunas… - Proceedings of the …, 2009 - National Acad Sciences
Tobacco use is predicted to result in over 1 billion deaths worldwide by the end of the 21st
century. How genetic variation contributes to the observed differential predisposition in the …
century. How genetic variation contributes to the observed differential predisposition in the …
Sleeping Beauty transposon‐mediated gene therapy for prolonged expression
Abstract The Sleeping Beauty (SB) transposon system represents a new vector for non‐viral
gene transfer that melds advantages of viruses and other forms of naked DNA transfer. The …
gene transfer that melds advantages of viruses and other forms of naked DNA transfer. The …
DNA transposons in vertebrate functional genomics
Genome sequences of many model organisms of developmental or agricultural importance
are becoming available. The tremendous amount of sequence data is fuelling the next …
are becoming available. The tremendous amount of sequence data is fuelling the next …
Target-site preferences of Sleeping Beauty transposons
The Sleeping Beauty (SB) transposon is a Tc1/mariner family transposon that has
applications in vertebrate animals for gene transfer, gene-tagging, and human gene therapy …
applications in vertebrate animals for gene transfer, gene-tagging, and human gene therapy …