Malignant pleural effusion (MPE) is a common but serious condition that is related with poor
quality of life, morbidity and mortality. Its incidence and associated healthcare costs are …

Introduction 3. NF-kappaB activation pathways 3.1. Protein components in the NF-kappaB
family 3.2. The pathways leading to NF-kappaB activation 4. NF-kappaB's cellular functions …

Systematic identification of protein-drug interaction networks is crucial to correlate complex
modes of drug action to clinical indications. We introduce a novel computational strategy to …

Bioluminescence refers to the process of visible light emission in living organisms.
Bioluminescence imaging is a powerful methodology that has been developed over the last …

Malignant pleural effusion (MPE) poses a significant clinical problem. Current nonetiologic
management is suboptimal in terms of efficacy and safety. In light of recent research …

Chronic inflammation is linked to carcinogenesis in several organ systems. In the lungs, NF-
κB, a central effector of inflammatory responses, is frequently activated in non-small-cell lung …

Mast cells (MCs) have been identified in various tumors; however, the role of these cells in
tumorigenesis remains controversial. Here, we quantified MCs in human and murine …

Malignant pleural effusion (MPE) is a common complication of thoracic and extrathoracic
malignancies and is associated with high mortality and elevated costs to healthcare …

Tumor necrosis factor (TNF)-α is present in the microenvironment of human tumors,
including malignant pleural effusion (MPE). Although the cytokine is produced in the pleural …

Dimethylfumarate (DMF) inhibits signals transmitted by Rel proteins and is used for the
treatment of inflammatory skin diseases such as psoriasis, but potential effects of DMF on …