Small-cell lung cancer (SCLC) is an aggressive lung cancer subtype and its first-line
treatment has remained unchanged for decades. In recent years, immunotherapy has …

The adaptation of natural killer (NK) cells to conditions in the microenvironment of tumors is
deeply affected by their metabolic activity, itself a result of nutrient availability and the …

An effective systemic mechanism regulates tumor development and progression; thus, a
rational design in a one‐stone‐two‐birds strategy is meant for cancer treatment. Herein, a …

Due to increased reliance on glycolysis, which produces lactate, monocarboxylate
transporters (MCTs) are often upregulated in cancer. MCT4 is associated with the export of …

Increasing numbers of studies have shown that tumor cells prefer fermentative glycolysis
over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even …

Ferroptosis has garnered considerable attention benefiting from its remarkable potential in
fighting malignant tumors. Its occurrence largely relies the overwhelming accumulation of …

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized
by excessive deposition of fibrotic connective tissue in the lungs. Emerging evidence …

Metabolic compartmentalization of stroma-rich tumors, like pancreatic ductal
adenocarcinoma (PDAC), greatly contributes to malignancy. This involves cancer cells …

Various cancer cells overexpress L-type amino acid transporter 1 (LAT1) to take up a large
number of neutral amino acids such as phenylalanine and methionine, and LAT1 transporter …

Abnormal tumor metabolism creates a complex tumor immune microenvironment that plays
a dominant role in the metastasis of triple-negative breast cancer (TNBC). TNBC is …