The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …

Conformational heterogeneity is a defining hallmark of intrinsically disordered proteins and
protein regions (IDRs). The functions of IDRs and the emergent cellular phenotypes they …

Simple Summary Localized prostate cancer has a favorable prognosis and can be
effectively treated with radiotherapy, as well as therapies that target hormone production and …

Intrinsically disordered proteins (IDPs) are highly dynamic biomolecules that rapidly
interconvert among many structural conformations. These dynamic biomolecules are …

Transcription factors (TFs) control specificity and activity of gene transcription, but whether a
relationship between these two features exists is unclear. Here we provide evidence for an …

Cell identity is orchestrated through an interplay between transcription factor (TF) action and
genome architecture. The mechanisms used by TFs to shape three-dimensional (3D) …

Over the past 30 years, Nature Structural & Molecular Biology (NSMB) has covered an
enormous breadth of subjects in the broad field of molecular and structural biology. Here …

The inclusion of microexons by alternative splicing is frequent in neuronal proteins. The
roles of these sequences are in most cases unknown, but changes in their degree of …

The emergence of phase separation phenomena among macromolecules has identified
biomolecular condensates as fundamental cellular organizers. These condensates …

The workshop held in the Netherlands from October 20–22, 2023, united 27 scientists from
academia, healthcare, and industry representing 11 countries, alongside four patient and …