Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

The placenta is the first organ to form during mammalian embryogenesis. Problems in its
formation and function underlie many aspects of early pregnancy loss and pregnancy …

Background The identification of high-risk stage II colon cancers is key to the selection of
patients who require adjuvant treatment after surgery. Microarray-based multigene …

Blastocyst formation marks the segregation of the first two cell lineages in the mammalian
preimplantation embryo: the inner cell mass (ICM) that will form the embryo proper and the …

Trophectoderm (TE), the first differentiated cell lineage of mammalian embryogenesis, forms
the placenta, a structure unique to mammalian development. The differentiation of TE is a …

Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila
melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) …

Early mammalian embryogenesis is controlled by mechanisms governing the balance
between pluripotency and differentiation. The expression of early lineage-specific genes can …

It has been thought that early inner cell mass (ICM) is a homogeneous population and that
cell position in the ICM leads to the formation of two lineages, epiblast (EPI) and primitive …

Abstract The Polycomb group (PcG) proteins are transcriptional repressors that regulate
lineage choices during development and differentiation. Recent studies have advanced our …

CDX2 is a recently cloned homeobox gene that encodes an intestine-specific transcription
factor, expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to …