Tyrosinase is a multi-copper enzyme widely distributed in different organisms, including
plants & mammals, etc., which is responsible for pigmentations, undesired browning of fruits …

In the continuous scientific search for new safe and effective drugs, there has recently been
a rediscovery of natural substances as a potential reservoir of innovative therapeutic …

Quantitative structure–activity relationship models for the prediction of mode of toxic action
(MOA) of 221 phenols to the ciliated protozoan Tetrahymena pyriformis using atom-based …

Ferula communis (L.), a plant belonging to Apiaceae, is widely present in Sardinia, Italy.
Currently, interest in F. communis focuses on the presence of two chemotypes in the wild …

The ubiquitin-proteasome pathway (UPP) is the primary degradation system of short-lived
regulatory proteins. Cellular processes such as the cell cycle, signal transduction, gene …

In many absorption, distribution, metabolism, and excretion (ADME) modeling problems,
imbalanced data could negatively affect classification performance of machine learning …

In the preset report, for the first time, support vector machine (SVM), artificial neural network
(ANN), Bayesian networks (BNs), k‐nearest neighbor (k‐NN) are applied and compared on …

The tyrosinase is a bifunctional, copper-containing enzyme widely distributed in the
phylogenetic tree. This enzyme is involved in the production of melanin and some other …

Quantitative Structure-Activity Relationship (QSAR) modeling has been widely used in
medicinal chemistry and computational toxicology for many years. Today, as the amount of …

Computational studies have significantly advanced the understanding of tyrosinase (TYR)
function, mechanism, and inhibition, accelerating the development of more effective and …