Animal models play an indispensable role in the study of human diseases. However, animal
models of different diseases do not fully mimic the complex internal environment of humans …

Intravital microscopy has become increasingly popular over the past few decades because it
provides high-resolution and real-time information about complex biological processes …

Myelodysplastic syndromes (MDSs) are a heterogeneous group of myeloid neoplasms with
defects in hematopoietic stem and progenitor cells (HSPCs) and possibly the HSPC niche …

Genetically targeted T cells promise to solve the feasibility and efficacy hurdles of adoptive T-
cell therapy for cancer. Selecting a target expressed in multiple-tumor types and that is …

Acute myeloid leukemia (AML) is a genetically heterogeneous hematologic malignancy,
which is initiated and driven by a rare fraction of leukemia stem cells (LSCs). Despite the …

Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long
persistence in the host, like all herpesviruses, by way of a latent infection. During latency …

In-depth analysis of the cellular and molecular mechanisms regulating human HSC function
will require a surrogate host that supports robust maintenance of transplanted human HSCs …

Introduction Immunodeficient mice engrafted with human immune systems support studies of
human hematopoiesis and the immune response to human‐specific pathogens. A significant …

Genetic manipulation of NOD/SCID (NS) mice has yielded numerous sub-strains with
specific traits useful for the study of human hematopoietic xenografts, each with unique …

A significant obstacle to the study of human cancer biology and the testing of human specific
immunotherapeutics is the paucity of translational models that recapitulate both the growth …