Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Along with a general decline in overall health, most chronic degenerative human diseases
are inherently associated with increasing age. Age-associated cognitive impairments and …

Summary The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for
sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in …

As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …

Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

Astrocytes participate in numerous aspects of central nervous system (CNS) physiology
ranging from ion balance to metabolism, and disruption of their physiological roles can …

Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of
patients with Alzheimer's and related dementias and cancer patients after chemo-or radio …

Objective Oxidative stress (OS) is associated with accelerated aging. Previous studies have
suggested a possible relationship between OS and frailty but this association remains …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease and
disability in the elderly; it is estimated to account for 60%–70% of all cases of dementia …

The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …