Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …

Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …

Adenosine-to-inosine (A-to-I) editing is the most prevalent type of RNA editing in animals,
and it occurs in fungi specifically during sexual reproduction. However, it is debatable …

Dynamic processes are ubiquitous and essential in living cells. To properly understand
these processes, it is imperative to measure them in a time-dependent way and analyze the …

Microtubules are dynamic polymers of αβ-tubulin that form diverse cellular structures, such
as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control …

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to
elongate in anaphase. However, although some candidate proteins are implicated in this …

During metaphase, chromosome position at the spindle equator is regulated by the forces
exerted by kinetochore microtubules and polar ejection forces. However, the role of forces …

All living organisms must transmit genetic information through successive generations, and
all six eukaryotic supergroups utilize a mitotic spindle to accomplish this task. The mitotic …

Anaphase B spindle elongation is characterized by the sliding apart of overlapping
antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate …

Kinesin-8 motors regulate the size of microtubule structures, using length-dependent
accumulation at the plus end to preferentially disassemble long microtubules. Despite …