The human lens: an antioxidant-dependent tissue revealed by the role of caffeine

M Ruiss, O Findl, M Kronschläger - Ageing research reviews, 2022 - Elsevier
Cataract is the leading cause of blindness worldwide and surgery is the only option to treat
the disease. Although the surgery is considered to be relatively safe, complications may …

Current trends in the pharmacotherapy of cataracts

SH Heruye, LN Maffofou Nkenyi, NU Singh… - Pharmaceuticals, 2020 - mdpi.com
Cataracts, one of the leading causes of preventable blindness worldwide, refers to lens
degradation that is characterized by clouding, with consequent blurry vision. As life …

[HTML][HTML] Substrate promiscuity of the NdmCDE N7-demethylase enzyme complex

MB Mock, S Zhang, B Pniak, N Belt, MK Witherspoon… - Biotechnology …, 2021 - Elsevier
Methylxanthines, including caffeine and theophylline, are a class of natural and synthetic
compounds with important roles in food, cosmetics, and medicine. These compounds are …

Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

H Abdelkader, RG Alany… - Journal of Pharmacy and …, 2015 - academic.oup.com
Objectives The search for anticataract drugs has been continuing for decades; some
treatments no longer exist but antioxidants are still of much interest. Key findings The …

DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model

F Wang, J Ma, F Han, X Guo, L Meng, Y Sun, C Jin… - Scientific reports, 2016 - nature.com
Abstract DL-3-n-butylphthalide (NBP) is a therapeutic drug used for ischemic stroke
treatment. Here, we investigated the impact of NBP on the development of rat diabetic …

Drug delivery to the lens for the management of cataracts

TR Thrimawithana, ID Rupenthal, SS Räsch… - Advanced drug delivery …, 2018 - Elsevier
Cataracts are one of the most prevalent diseases of the lens, affecting its transparency and
are the leading cause of reversible blindness in the world. The clarity of the lens is essential …

Microbial metabolism of caffeine and potential applications in bioremediation

MB Mock, RM Summers - Journal of Applied Microbiology, 2024 - academic.oup.com
With increasing global consumption of caffeine-rich products, such as coffee, tea, and
energy drinks, there is also an increase in urban and processing waste full of residual …

[HTML][HTML] Expression of the microRNAs hsa-miR-15a and hsa-miR-16-1 in lens epithelial cells of patients with age-related cataract

Y Li, S Liu, F Zhang, P Jiang, X Wu… - International journal of …, 2015 - ncbi.nlm.nih.gov
This study aimed to examine and analyze the expression levels of hsa-miR-15a and hsa-
miR-16-1 in lens epithelial cells from patients with age-related cataract to understand better …

The potential health benefits of dietary natural plant products in age related eye diseases

EU Ikonne, VO Ikpeazu, EA Ugbogu - Heliyon, 2020 - cell.com
In the past decade, there has been a tremendous increase in the number of cases of age-
related eye diseases such as age-related macular degeneration (AMD), cataract, diabetic …

Recent advances in the processing of green tea biomolecules using ethyl lactate. A review

D Villanueva-Bermejo, G Reglero, T Fornari - Trends in Food Science & …, 2017 - Elsevier
Background Green tea and its decaffeinated products are foodstuffs which involve a great
commercial market due to their interesting healthy properties. Catechins are the main …