Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

It has been known for over a century that the basic organization of the retina is conserved
across vertebrates. It has been equally clear that retinal cells can be classified into …

Many neurodegenerative diseases cause degeneration of specific types of neurons. For
example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact …

We previously used single-cell transcriptomic analysis to characterize human fetal retinal
development and assessed the degree to which retinal organoids recapitulate normal …

Background Nitric oxide-releasing drugs are used for cardiovascular diseases; however,
their effects on the tumor immune microenvironment are less clear. Therefore, this study …

Retinal organoids (ROs) derived from human pluripotent stem cells (hPSCs) have become a
promising model in vitro to recapitulate human retinal development, which can be further …

Understanding the formation of the complex nervous system hinges on decoding the
mechanism that specifies a vast array of neuronal types, each endowed with a unique …

Glaucoma and other optic neuropathies affect millions of people worldwide, ultimately
causing progressive and irreversible degeneration of retinal ganglion cells (RGCs) and …

The emergence of retinal progenitor cells and differentiation to various retinal cell types
represent fundamental processes during retinal development. Herein, we provide a …

Retinal ganglion cells (RGCs) relay visual information from the eye to the brain. RGCs are
the first cell type generated during retinal neurogenesis. Loss of function of the transcription …