The link between inflammation and cancer was first proposed by R. Virchow. It was later
realized that it is chronic inflammation that may promote cancer, whereas acute inflammation …

Conclusions Overall these studies clearly demonstrate that NF-κB plays a critical role in
tumorigenesis. Similarity, suppression of NF-κB has the ability to inhibit various steps in the …

The clear cell renal cell carcinoma (ccRCC) microenvironment consists of many different cell
types and structural components that play critical roles in cancer progression and drug …

The process of tumorigenesis requires cellular transformation, hyperproliferation, invasion,
angiogenesis, and metastasis. Several genes that mediate these processes are regulated …

Betulinic acid (BA), a pentacyclic triterpene isolated from the bark of the white birch tree, has
been reported to be a selective inducer of apoptosis in tumor cells. It also exhibits anti …

To investigate the role of the TNF-α in the development of laser-induced choroidal
neovascularization (CNV) in a mouse model. Four separate laser burns were applied to …

Angiogenesis is essential during development and in pathological conditions such as
chronic inflammation and cancer progression. Inhibition of angiogenesis by targeting …

The cytokines lymphotoxin (LT) α, β and their receptor (LTβR) belong to the tumor necrosis
factor (TNF) superfamily, whose founder—TNFα—was initially discovered due to its tumor …

The lymphotoxin-β receptor (LTβR) is a tumor necrosis factor receptor family member critical
for the development and maintenance of various lymphoid microenvironments. Herein, we …

Cytokines have been implicated in a variety of physiological processes involving lymphoid
tissue development, lymphocyte activation, and control of regenerative processes such as …