There is growing evidence that patients with Type 2 diabetes have an increased risk of
developing Parkinson's disease and share similar dysregulated pathways suggesting …

Parkinson's disease (PD) is one of the common progressive neurodegenerative disorders
with several motor and non-motor symptoms. Most of the motor symptoms may appear at a …

Abstract Insulin and Insulin Growth Factor-1 (IGF-1) play a major role in body homeostasis
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …

Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic
diseases, share remarkably similar dysregulated pathways. Exposure to environmental …

Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the
central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide …

Along with the increase in life expectancy over the last century, the prevalence of age-
related disorders, such as neurodegenerative diseases continues to rise. This is the case of …

Impairments in systematic and regional glucose metabolism exist in patients with
Parkinson's disease (PD) at every stage of the disease course, and such impairments are …

The insulin-like growth factor 1 (IGF1) signaling pathway has emerged as a major regulator
of the aging process, from rodents to humans. However, given the pleiotropic actions of …

Aims Brain insulin resistance (ie, decreased insulin/insulin‐like growth factor‐1 [IGF‐1]
signalling) may play a role in the pathophysiology of Parkinson's disease (PD), and several …

Parkinson's disease (PD) is a neurodegenerative disorder, characterized by motor and non-
motor symptoms, that still lacks of a disease-modifying treatment. Consistent evidence …