The molecular mechanisms underlying mussel adhesion

Y Li, Y Cao - Nanoscale Advances, 2019 - pubs.rsc.org
Marine mussels are able to firmly affix on various wet surfaces by the overproduction of
special mussel foot proteins (mfps). Abundant fundamental studies have been conducted to …

Protein nanomechanics in biological context

J Alegre-Cebollada - Biophysical Reviews, 2021 - Springer
How proteins respond to pulling forces, or protein nanomechanics, is a key contributor to the
form and function of biological systems. Indeed, the conventional view that proteins are able …

Chemical unfolding of protein domains induces shape change in programmed protein hydrogels

LR Khoury, I Popa - Nature communications, 2019 - nature.com
Programmable behavior combined with tailored stiffness and tunable biomechanical
response are key requirements for developing successful materials. However, these …

Mechanical regulation of talin through binding and history-dependent unfolding

N Dahal, S Sharma, B Phan, A Eis, I Popa - Science Advances, 2022 - science.org
Talin is a force-sensing multidomain protein and a major player in cellular
mechanotransduction. Here, we use single-molecule magnetic tweezers to investigate the …

Cation-induced shape programming and morphing in protein-based hydrogels

LR Khoury, M Slawinski, DR Collison, I Popa - Science advances, 2020 - science.org
Smart materials that are capable of memorizing a temporary shape, and morph in response
to a stimulus, have the potential to revolutionize medicine and robotics. Here, we introduce …

Building block aspect ratio controls assembly, architecture, and mechanics of synthetic and natural protein networks

MDG Hughes, S Cussons, BS Hanson… - Nature …, 2023 - nature.com
Fibrous networks constructed from high aspect ratio protein building blocks are ubiquitous in
nature. Despite this ubiquity, the functional advantage of such building blocks over globular …

Binding-induced stabilization measured on the same molecular protein substrate using single-molecule magnetic tweezers and heterocovalent attachments

N Dahal, J Nowitzke, A Eis, I Popa - The Journal of Physical …, 2020 - ACS Publications
Binding-induced mechanical stabilization plays key roles in proteins involved in muscle
contraction, cellular mechanotransduction, or bacterial adhesion. Because of the vector …

Mechanical deformation accelerates protein ageing

J Valle‐Orero, JA Rivas‐Pardo… - Angewandte Chemie …, 2017 - Wiley Online Library
A hallmark of tissue ageing is the irreversible oxidative modification of its proteins. We show
that single proteins, kept unfolded and extended by a mechanical force, undergo …

Information rates of controlled protein interactions using terahertz communication

H Elayan, AW Eckford, RS Adve - IEEE Transactions on …, 2020 - ieeexplore.ieee.org
In this work, we present a paradigm bridging electromagnetic (EM) and molecular
communication through a stimuli-responsive intra-body model. It has been established that …

Study of biomechanical properties of protein-based hydrogels using force-clamp rheometry

LR Khoury, J Nowitzke, K Shmilovich, I Popa - Macromolecules, 2018 - ACS Publications
Protein-based hydrogels are unique materials that combine the durability and wetting
properties of polymeric hydrogels with the biocompatibility and elasticity of proteins …