Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

Abstract Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …

Isoprenoids comprise a large class of chemicals of significant interest due to their diverse
properties. Biological production of isoprenoids is considered to be the most efficient way for …

Polyunsaturated fatty acids (PUFAs) of the ω-3 and ω-6 class (eg, α-linolenic acid, linoleic
acid) are essential for maintaining biofunctions in mammalians like humans. Due to the fact …

The assembly of large recombinant DNA encoding a whole biochemical pathway or genome
represents a significant challenge. Here, we report a new method, DNA assembler, which …

Plants possess myriads of secondary metabolites with a broad spectrum of health-promoting
benefits. To date, plant extraction is still the primary route to produce high-value natural …

The use of enzymes and whole bacterial cells has allowed the production of a plethora of
compounds that have been used for centuries in foods and beverages. However, only …

The construction of mitotically stable yeast strains for heterologous gene or pathway
expression often requires chromosomal integration. However, transcription levels vary …

Flavonoids are valuable natural products widely used in human health and nutrition. Recent
advances in synthetic biology and metabolic engineering have yielded improved strain titers …

The identification of optimal genotypes that result in improved production of recombinant
metabolites remains an engineering conundrum. In the present work, various strategies to …