The re-emergence of natural products for drug discovery in the genomics era
AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …
use has diminished in the past two decades, in part because of technical barriers to …
[HTML][HTML] Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders
MT Kabir, MH Rahman, M Shah, MR Jamiruddin… - Biomedicine & …, 2022 - Elsevier
Abstract Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …
Two-step pathway for isoprenoid synthesis
AO Chatzivasileiou, V Ward… - Proceedings of the …, 2019 - National Acad Sciences
Isoprenoids comprise a large class of chemicals of significant interest due to their diverse
properties. Biological production of isoprenoids is considered to be the most efficient way for …
properties. Biological production of isoprenoids is considered to be the most efficient way for …
Production strategies and applications of microbial single cell oils
K Ochsenreither, C Glück, T Stressler… - Frontiers in …, 2016 - frontiersin.org
Polyunsaturated fatty acids (PUFAs) of the ω-3 and ω-6 class (eg, α-linolenic acid, linoleic
acid) are essential for maintaining biofunctions in mammalians like humans. Due to the fact …
acid) are essential for maintaining biofunctions in mammalians like humans. Due to the fact …
DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways
The assembly of large recombinant DNA encoding a whole biochemical pathway or genome
represents a significant challenge. Here, we report a new method, DNA assembler, which …
represents a significant challenge. Here, we report a new method, DNA assembler, which …
Optimizing oleaginous yeast cell factories for flavonoids and hydroxylated flavonoids biosynthesis
Plants possess myriads of secondary metabolites with a broad spectrum of health-promoting
benefits. To date, plant extraction is still the primary route to produce high-value natural …
benefits. To date, plant extraction is still the primary route to produce high-value natural …
Enzymatic and whole cell catalysis: finding new strategies for old processes
CCCR De Carvalho - Biotechnology advances, 2011 - Elsevier
The use of enzymes and whole bacterial cells has allowed the production of a plethora of
compounds that have been used for centuries in foods and beverages. However, only …
compounds that have been used for centuries in foods and beverages. However, only …
Characterization of chromosomal integration sites for heterologous gene expression in Saccharomyces cerevisiae
The construction of mitotically stable yeast strains for heterologous gene or pathway
expression often requires chromosomal integration. However, transcription levels vary …
expression often requires chromosomal integration. However, transcription levels vary …
Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy
Flavonoids are valuable natural products widely used in human health and nutrition. Recent
advances in synthetic biology and metabolic engineering have yielded improved strain titers …
advances in synthetic biology and metabolic engineering have yielded improved strain titers …
Engineering Central Metabolic Pathways for High-Level Flavonoid Production in Escherichia coli
E Leonard, KH Lim, PN Saw… - Applied and …, 2007 - Am Soc Microbiol
The identification of optimal genotypes that result in improved production of recombinant
metabolites remains an engineering conundrum. In the present work, various strategies to …
metabolites remains an engineering conundrum. In the present work, various strategies to …