The pharmacogenetics of antidepressants has been not only a challenging but also
frustrating research field since its birth in the 1990s. Indeed, great expectations followed the …

The complement system is part of the innate immune response responsible for removing
pathogens and cellular debris, in addition to helping to refine CNS neuronal connections via …

Scaffolding proteins represent an evolutionary solution to controlling the specificity of
information transfer in intracellular networks. They are highly concentrated in complexes …

Mouse models have been indispensable for elucidating normal and pathological processes
that influence learning and memory. A widely used method for assessing these cognitive …

Previous studies from our lab have demonstrated that mild cognitive impairments identified
early in life are predictive of cognitive deficits that develop with age, suggesting that …

Previous studies from our laboratory have shown that environmental enrichment (EE) in
young rats results in improved learning ability and enhanced metabotropic glutamate …

Synaptic plasticity represents the long lasting activity-related strengthening or weakening of
synaptic transmission, whose well-characterized types are the long term potentiation and …

As the population of people aged 60 or older continues to rise, it has become increasingly
important to understand the molecular basis underlying age-related cognitive decline. In …

In recent years, the glutamatergic system has been implicated in the development and
treatment of psychiatric disorders. Glutamate signaling is processed by different receptors …

Schizophrenia is one of the most debilitating psychiatric diseases with a lifetime prevalence
of approximately 1%. Although the specific molecular underpinnings of schizophrenia are …