Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies

S Luo, Y Liang, THT Wong… - International journal …, 2022 - academic.oup.com
Background To summarize modifiable factors for coronavirus disease 2019 (COVID-19)
suggested by Mendelian randomization studies. Methods In this systematic review, we …

Whole-genome sequencing reveals host factors underlying critical COVID-19

A Kousathanas, E Pairo-Castineira, K Rawlik… - Nature, 2022 - nature.com
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic
variation influences the development of illness requiring critical care or hospitalization,–after …

Host genetic determinants of COVID‐19 susceptibility and severity: A systematic review and meta‐analysis

S Eshetie, P Jullian, B Benyamin… - Reviews in Medical …, 2023 - Wiley Online Library
Genome‐wide association studies (GWASs) have identified single nucleotide
polymorphisms (SNPs) associated with susceptibility and severity of coronavirus disease …

Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity

S Zhang, J Cooper-Knock, AK Weimer, M Shi… - Cell systems, 2022 - cell.com
The determinants of severe COVID-19 in healthy adults are poorly understood, which limits
the opportunity for early intervention. We present a multiomic analysis using machine …

The early-life exposome modulates the effect of polymorphic inversions on DNA methylation

N Carreras-Gallo, A Cáceres, L Balagué-Dobón… - Communications …, 2022 - nature.com
Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play
important roles in evolution, environmental adaptation, and complex traits. We investigated …

IDEAS: individual level differential expression analysis for single-cell RNA-seq data

M Zhang, S Liu, Z Miao, F Han, R Gottardo, W Sun - Genome biology, 2022 - Springer
We consider an increasingly popular study design where single-cell RNA-seq data are
collected from multiple individuals and the question of interest is to find genes that are …

[HTML][HTML] SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells

Q Hammer, J Dunst, W Christ, F Picarazzi, M Wendorff… - Cell reports, 2022 - cell.com
Natural killer (NK) cells are innate immune cells that contribute to host defense against virus
infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Psychiatric polygenic risk as a predictor of COVID-19 risk and severity: insight into the genetic overlap between schizophrenia and COVID-19

M Alemany-Navarro, S Diz-de Almeida, R Cruz… - Translational …, 2023 - nature.com
Despite the high contagion and mortality rates that have accompanied the coronavirus
disease-19 (COVID-19) pandemic, the clinical presentation of the syndrome varies greatly …

Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19

A Kousathanas, E Pairo-Castineira, K Rawlik… - medRxiv, 2021 - medrxiv.org
Critical illness in COVID-19 is caused by inflammatory lung injury, mediated by the host
immune system. We and others have shown that host genetic variation influences the …

Poking COVID-19: insights on genomic constraints among immune-related genes between Qatari and Italian populations

H Mbarek, M Cocca, Y Al-Sarraj, C Saad, M Mezzavilla… - Genes, 2021 - mdpi.com
Host genomic information, specifically genomic variations, may characterize susceptibility to
disease and identify people with a higher risk of harm, leading to better targeting of care and …