Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies
Background To summarize modifiable factors for coronavirus disease 2019 (COVID-19)
suggested by Mendelian randomization studies. Methods In this systematic review, we …
suggested by Mendelian randomization studies. Methods In this systematic review, we …
Whole-genome sequencing reveals host factors underlying critical COVID-19
A Kousathanas, E Pairo-Castineira, K Rawlik… - Nature, 2022 - nature.com
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic
variation influences the development of illness requiring critical care or hospitalization,–after …
variation influences the development of illness requiring critical care or hospitalization,–after …
Host genetic determinants of COVID‐19 susceptibility and severity: A systematic review and meta‐analysis
S Eshetie, P Jullian, B Benyamin… - Reviews in Medical …, 2023 - Wiley Online Library
Genome‐wide association studies (GWASs) have identified single nucleotide
polymorphisms (SNPs) associated with susceptibility and severity of coronavirus disease …
polymorphisms (SNPs) associated with susceptibility and severity of coronavirus disease …
Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity
The determinants of severe COVID-19 in healthy adults are poorly understood, which limits
the opportunity for early intervention. We present a multiomic analysis using machine …
the opportunity for early intervention. We present a multiomic analysis using machine …
The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play
important roles in evolution, environmental adaptation, and complex traits. We investigated …
important roles in evolution, environmental adaptation, and complex traits. We investigated …
IDEAS: individual level differential expression analysis for single-cell RNA-seq data
We consider an increasingly popular study design where single-cell RNA-seq data are
collected from multiple individuals and the question of interest is to find genes that are …
collected from multiple individuals and the question of interest is to find genes that are …
[HTML][HTML] SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Natural killer (NK) cells are innate immune cells that contribute to host defense against virus
infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Psychiatric polygenic risk as a predictor of COVID-19 risk and severity: insight into the genetic overlap between schizophrenia and COVID-19
M Alemany-Navarro, S Diz-de Almeida, R Cruz… - Translational …, 2023 - nature.com
Despite the high contagion and mortality rates that have accompanied the coronavirus
disease-19 (COVID-19) pandemic, the clinical presentation of the syndrome varies greatly …
disease-19 (COVID-19) pandemic, the clinical presentation of the syndrome varies greatly …
Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19
Critical illness in COVID-19 is caused by inflammatory lung injury, mediated by the host
immune system. We and others have shown that host genetic variation influences the …
immune system. We and others have shown that host genetic variation influences the …
Poking COVID-19: insights on genomic constraints among immune-related genes between Qatari and Italian populations
Host genomic information, specifically genomic variations, may characterize susceptibility to
disease and identify people with a higher risk of harm, leading to better targeting of care and …
disease and identify people with a higher risk of harm, leading to better targeting of care and …