The early onset of colorectal cancer (CRC) in individuals younger than 50 years is an
emerging phenomenon, and obesity is a strong risk factor. Inflammatory mechanisms are …

The dysregulation of Notch signaling is found in many cancers and is closely related to
cancer progression. As an important Notch receptor, abnormal Notch4 expression affects …

The Notch signalling pathway is one of the most conserved and well-characterised
pathways involved in cell fate decisions and the development of many diseases, including …

Cancer cell heterogeneity is a key contributor to therapeutic failure and post-treatment
recurrence. Targeting cell subpopulations responsible for chemoresistance and recurrence …

Metastasis is a leading cause of mortality and poor prognosis in colorectal cancer (CRC).
Thus, the identification of new compounds targeting cell migration represents a major …

Resistance to anti-cancer treatments is a critical and widespread health issue that has
brought serious impacts on lives, the economy and public policies. Mounting research has …

Anti-metabolite drugs prevent the synthesis of essential cell growth compounds. 5-
fluorouracil is used as an anti-metabolic drug in various cancers in the first stage of …

Cancer has been traditionally viewed as a disease characterised by excessive and
uncontrolled proliferation, leading to the development of cytotoxic therapies against highly …

Background Colorectal cancer (CRC) is one of the most prevalent digestive cancers, ranking
the 2nd cause of cancer-related fatality worldwide. The worldwide burden of CRC is …

Colorectal cancer (CRC) is a malignant tumor with a high incidence, ranking first among
gastrointestinal malignancies. We investigated the impact of polyphyllin I (PPI), a natural …