Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Primary aging is the progressive and inevitable process of bodily deterioration during
adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and …

Safety of healthcare workers in hospitals is a major concern during the COVID-19 pandemic.
Being exposed for several working hours per day to infected patients, nurses dealing with …

Skeletal muscle health is a strong predictor of overall health and longevity. Pathologies
affecting skeletal muscle such as cancer cachexia, intensive care unit treatment, muscular …

Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Transmission of external stimuli to intracellular effector proteins via signalling …

Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …

Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes,
cancer, renal, and cardiac failure and in aging-sarcopenia. In these catabolic conditions the …

Extracellular superoxide dismutase (EcSOD) is the only extracellular scavenger of
superoxide anion (O 2.-) with unique binding capacity to cell surface and extracellular matrix …

Excessive production of mitochondrial reactive oxygen species (mROS) is strongly
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …

Fast-twitch glycolytic fibers are more vulnerable than slow-twitch oxidative fibers under a
variety of atrophic conditions related to signaling transduction of Forkhead box O family …