Neuroinflammation is the fundamental immune response against multiple factors in the
central nervous system and is characterized by the production of inflammatory mediators …

The glycosides of two flavonoids, naringin and naringenin, are found in various citrus fruits,
bergamots, tomatoes, and other fruits. These phytochemicals are associated with multiple …

Oxidative and inflammatory signaling pathways have been identified as important targets for
mitigating hypoxic stress-induced neurological complications. Thus, the effects of …

Background Adaptogens are generally referred to the substances, mostly found in plants,
which non-specifically increase resilience and chances of survival by activation of signaling …

Numerous animal and human studies have assessed the relationship between polyphenols
and outcomes related to depression. However, no comprehensive synthesis of the main …

Rationale Emerging evidence indicates that persistent alcohol consumption escalates
psychosocial trauma achieved by social defeat stress (SDS)-induced neurobiological …

Social defeat stress (SDS) due to changes in biochemical functions has been implicated in
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …

The brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response
element-binding protein (BDNF/TrkB/CREB) signaling pathway is a critical therapeutic target …

Derangements of neuroimmune, neurotrophic and neurochemical homeostasis have
important implications in psychosocial stress-induced psychopathologies. Whether …

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are prevalently co-
occurring, important risk factors for a broad array of neuropsychiatric diseases. To date, how …