Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes,
enzymes do not catalyze many of the transformations favored by synthetic chemists. Either …

Bacterial microcompartments (BMCs) are self-assembling organelles that consist of an
enzymatic core that is encapsulated by a selectively permeable protein shell. The potential …

Chemical modification of enzymes and immobilization used to be considered as separate
ways to improve enzyme properties. This review shows how the coupled use of both tools …

Abstract Flavin-dependent 'ene'-reductases (EREDs) are exquisite catalysts for effecting
stereoselective reductions. Although these reactions typically proceed through a hydride …

Recent reports have suggested that the establishment of industrially relevant enzyme
collections from environmental genomes has become a routine procedure. Across the …

What happens inside an enzyme's active site to allow slow and difficult chemical reactions to
occur so rapidly? This question has occupied biochemists' attention for a long time …

Recent years have witnessed an explosion of interest in understanding the role of
conformational dynamics both in the evolution of new enzymatic activities from existing …

Enzymes are the proteins responsible for the catalysis of life. Enzymes sharing a common
ancestor as defined by sequence and structure similarity are grouped into families and …

How individual enzymes evolved is relatively well understood. However, individual enzymes
rarely confer a physiological advantage on their own. Judging by its current state, the …

Polylactic acid (PLA) is a biodegradable polyester derived from renewable resources, which
is a leading candidate for the replacement of traditional petroleum-based polymers. Since …