Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors
The eukaryotic RNA exosome is an essential and conserved protein complex that can
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …
RNA-quality control by the exosome
The exosome complex of 3′→ 5′ exonucleases is an important component of the RNA-
processing machinery in eukaryotes. This complex functions in the accurate processing of …
processing machinery in eukaryotes. This complex functions in the accurate processing of …
Exosome-mediated recognition and degradation of mRNAs lacking a termination codon
A Van Hoof, PA Frischmeyer, HC Dietz, R Parker - Science, 2002 - science.org
One role of messenger RNA (mRNA) degradation is to maintain the fidelity of gene
expression by degrading aberrant transcripts. Recent results show that mRNAs without …
expression by degrading aberrant transcripts. Recent results show that mRNAs without …
[HTML][HTML] Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae
A Tudek, PS Krawczyk, S Mroczek, R Tomecki… - Nature …, 2021 - nature.com
The polyadenosine tail (poly [A]-tail) is a universal modification of eukaryotic messenger
RNAs (mRNAs) and non-coding RNAs (ncRNAs). In budding yeast, Pap1-synthesized …
RNAs (mRNAs) and non-coding RNAs (ncRNAs). In budding yeast, Pap1-synthesized …
[HTML][HTML] Reconstitution, activities, and structure of the eukaryotic RNA exosome
The RNA exosome is a multisubunit 3′ to 5′ exoribonuclease complex that participates in
degradation and processing of cellular RNA. To determine the activities and structure of the …
degradation and processing of cellular RNA. To determine the activities and structure of the …
Exoribonuclease superfamilies: structural analysis and phylogenetic distribution
Y Zuo, MP Deutscher - Nucleic acids research, 2001 - academic.oup.com
Exoribonucleases play an important role in all aspects of RNA metabolism. Biochemical and
genetic analyses in recent years have identified many new RNases and it is now clear that a …
genetic analyses in recent years have identified many new RNases and it is now clear that a …
Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae
S Kadaba, A Krueger, T Trice, AM Krecic… - Genes & …, 2004 - genesdev.cshlp.org
The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential
genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a …
genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a …
[HTML][HTML] “Cotranscriptionality”: the transcription elongation complex as a nexus for nuclear transactions
Much of the complex process of RNP biogenesis takes place at the gene cotranscriptionally.
The target for RNA binding and processing factors is, therefore, not a solitary RNA molecule …
The target for RNA binding and processing factors is, therefore, not a solitary RNA molecule …
[HTML][HTML] RNA quality control in eukaryotes
MK Doma, R Parker - Cell, 2007 - cell.com
Eukaryotic cells contain numerous RNA quality-control systems that are important for
shaping the transcriptome of eukaryotic cells. These systems not only prevent accumulation …
shaping the transcriptome of eukaryotic cells. These systems not only prevent accumulation …