Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has
been a versatile field of study for a long time for its diverse biological and medicinal …

During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

Broad‐spectrum antiviral agents targeting viral RNA‐dependent RNA polymerase (RdRp)
are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 …

The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …

Therapeutic options for coronaviruses remain limited. To address this unmet medical need,
we screened 5406 compounds, including United States Food and Drug Administration …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces mild or
asymptomatic COVID-19 in most cases, but some patients develop an excessive …

Introduction: The development of effective vaccines has partially mitigated the trend of the
SARS-CoV-2 pandemic; however, the need for orally administered antiviral drugs persists …

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
responsible for the coronavirus disease 19 (COVID-19) pandemic. Despite unprecedented …

Background: There is an urgent need for new antivirals with powerful therapeutic potential
and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons …