Aging and age-related neurodegeneration are both associated with the accumulation of
unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis …

Testing the predictions of the Mitochondrial Free Radical Theory of Ageing (MFRTA) has
provided a deep understanding of the role of reactive oxygen species (ROS) and …

Despite ongoing high energetic demands, brains do not always use glucose and oxygen in
a ratio that produces maximal ATP through oxidative phosphorylation. In some cases …

The fruits of Lycium barbarum are considered medicinal foods with high nutritional value
and bioactivity. In this study, we aimed to evaluate the effect of a crude L. barbarum …

Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial
electron transport chain complex I. It has been hypothesized that normal aging and age …

In mammals during aging, reactive oxygen species (ROS), produced by the mitochondrial
respiratory chain, cause oxidative damage of macromolecules leading to respiratory chain …

Recent findings indicate that perturbations of the mitochondrial electron transport chain
(METC) can cause extended longevity in evolutionarily diverse organisms. To uncover the …

Understanding how alterations in mitochondrial function in different cells and tissues
impacts the aging process remains one of the greatest challenges facing biogerontologists …

What is the nature of aging, and how best can we study it? Here, using a series of questions
that highlight differing perspectives about the nature of aging, we ask how data from …

Ageing is characterised at the molecular level by six transcriptional 'hallmarks of ageing',
that are commonly described as progressively affected as time passes. By contrast, the …