Monoubiquitylation of histone H2B (H2Bub1), catalyzed by the heterodimeric ubiquitin
ligase complex RNF20/40, regulates multiple molecular and biological processes. The …

Differentiation of embryonic stem (ES) cells from a pluripotent to a committed state involves
global changes in genome expression patterns. Gene activity is critically determined by …

The mechanisms responsible for maintaining genomic methylation imprints in mouse
embryos are not understood. We generated a knockout mouse in the Zfp57 locus encoding …

Although germline cells can form multipotential embryonic stem (ES)/embryonic germ (EG)
cells, these cells can be derived only from embryonic tissues, and such multipotent cells …

Diffuse midline gliomas (DMGs) bearing driver mutations of histone 3 lysine 27 (H3K27M)
are incurable brain tumors with unique epigenomes. Here, we generated a syngeneic …

To understand the molecular mechanisms underlying alterations in the pathophysiologic
status of dietary obesity, we examined hepatic genes differentially expressed in a long-term …

Murine bone marrow stromal cells differentiate not only into mesodermal derivatives, such
as osteocytes, chondrocytes, adipocytes, skeletal myocytes, and cardiomyocytes, but also …

Epigenetic modifications play an important role in modulating genome function. In mammals,
inappropriate epigenetic states can cause embryonic lethality and various acquired and …

OBJECTIVE Transient neonatal diabetes mellitus 1 (TNDM1) is the most common cause of
diabetes presenting at birth. Approximately 5% of the cases are due to recessive ZFP57 …

We reported previously that genistein enhances the expression of genes involved in fatty
acid catabolism through activation of peroxisome proliferator-activated receptor (PPAR) α in …