Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

While insomnia is the second most common mental disorder, progress in our understanding
of underlying neurobiological mechanisms has been limited. The present review addresses …

Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment
currently exists. Previous genome-wide association studies with up to 1.3 million subjects …

Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …

Since ancient times it is known that melancholia and sleep disturbances co-occur. The
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …

Insomnia is the second most prevalent mental disorder, with no sufficient treatment
available. Despite substantial heritability, insight into the associated genes and …

Genetic correlation (rg) analysis is used to identify phenotypes that may have a shared
genetic basis. Traditionally, rg is studied globally, considering only the average of the …

The UK Biobank project is a large prospective cohort study of~ 500,000 individuals from
across the United Kingdom, aged between 40-69 at recruitment. A rich variety of phenotypic …

Sleep reactivity is the trait‐like degree to which stress exposure disrupts sleep, resulting in
difficulty falling and staying asleep. Individuals with highly reactive sleep systems …