The ecology of chronic wasting disease in wildlife

LE Escobar, S Pritzkow, SN Winter, DA Grear… - Biological …, 2020 - Wiley Online Library
Prions are misfolded infectious proteins responsible for a group of fatal neurodegenerative
diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic …

Chronic wasting disease: a cervid prion infection looming to spillover

A Otero, CD Velásquez, J Aiken, D McKenzie - Veterinary Research, 2021 - Springer
The spread of chronic wasting disease (CWD) during the last six decades has resulted in
cervid populations of North America where CWD has become enzootic. This insidious …

North American and Norwegian chronic wasting disease prions exhibit different potential for interspecies transmission and zoonotic risk

S Pritzkow, D Gorski, F Ramirez… - The Journal of …, 2022 - academic.oup.com
Background Chronic wasting disease (CWD) is a rapidly spreading prion disorder affecting
various species of wild and captive cervids. The risk that CWD poses to cohabiting animals …

Update on chronic wasting disease (CWD) III

EFSA Panel on Biological Hazards (BIOHAZ)… - EFSA …, 2019 - Wiley Online Library
Abstract The European Commission asked EFSA for a Scientific Opinion: to revise the state
of knowledge about the differences between the chronic wasting disease (CWD) strains …

Chronic wasting disease (CWD) in cervids and the consequences of a mutable protein conformation

CJ Silva - ACS omega, 2022 - ACS Publications
Chronic wasting disease (CWD) is a prion disease of cervids (deer, elk, moose, etc.). It
spreads readily from CWD-contaminated environments and among wild cervids. As of 2022 …

Expression of Toll-like receptors in the cerebellum during pathogenesis of prion disease

X Liao, W Zhu, X Liao, W Liu, Y Hou… - Frontiers in Behavioral …, 2024 - frontiersin.org
Prion diseases, such as scrapie, entail the accumulation of disease-specific prion protein
(PrP Sc) within the brain. Toll-like receptors (TLRs) are crucial components of the pattern …

Inter-and intra-species conversion efficacies of Norwegian prion isolates estimated by serial protein misfolding cyclic amplification

E Harpaz, TT Vuong, L Tran, MA Tranulis… - Veterinary …, 2023 - Springer
Prion diseases, including chronic wasting disease (CWD) in cervids, are fatal
neurodegenerative disorders caused by the misfolding of cellular prion proteins. CWD is …

Transmission, strain diversity, and zoonotic potential of chronic wasting disease

S Pritzkow - Viruses, 2022 - mdpi.com
Chronic wasting disease (CWD) is a prion disease affecting several species of captive and
free-ranging cervids. In the past few decades, CWD has been spreading uncontrollably …

Pathogenesis, detection, and control of scrapie in sheep

ED Cassmann, JJ Greenlee - American journal of veterinary …, 2020 - Am Vet Med Assoc
In sheep, scrapie is a fatal neurologic disease that is caused by a misfolded protein called a
prion (designated PrP Sc). The normal cellular prion protein (PrP C) is encoded by an …

Chronic wasting disease modeling: an overview

SN Winter, LE Escobar - Journal of wildlife diseases, 2020 - meridian.allenpress.com
Chronic wasting disease (CWD) is an infectious and fatal prion disease occurring in the
family Cervidae. To update the research community regarding the status quo of CWD …