Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by virtually every
cell type. EVs have diverse biological activities, ranging from roles in development and …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Fluorescent tools have revolutionized our ability to probe biological dynamics, particularly at
the cellular level. Fluorescent sensors have been developed on several platforms, utilizing …

Fluorescent polymeric nanoparticles (FPNs) with aggregation-induced emission (AIE)
characteristics have attracted much attention for biomedical applications due to their …

Tail-anchored (TA) proteins insert post-translationally into the endoplasmic reticulum (ER),
the outer mitochondrial membrane (OMM) and peroxisomes. Whereas the GET pathway …

How can a self-organized cellular function evolve, adapt to perturbations, and acquire new
sub-functions? To make progress in answering these basic questions of evolutionary cell …

Most eukaryotic proteins are N-terminally acetylated. This modification can be recognized as
a signal for selective protein degradation (degron) by the N-end rule pathways. However …

Cell therapies represent a rapidly emerging class of new therapeutics. They are intended
and developed for the treatment of some of the most prevalent human diseases, including …

The best-known hallmarks of Parkinson's disease (PD) are the motor deficits that result from
the degeneration of dopaminergic neurons in the substantia nigra. Dopaminergic neurons …

Cells need to reliably control their proteome composition to maintain homeostasis and
regulate growth. How protein synthesis and degradation interplay to control protein …