How does the coagulation protease thrombin regulate cellular behaviour? The protease-
activated receptors (PARs) provide one answer. In concert with the coagulation cascade …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

The coagulation cascade and protease‐activated receptors (PARs) together provide an
elegant mechanism that links mechanical information in the form of tissue injury to cellular …

Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

Because of the role of thrombin and platelets in myocardial infarction and other pathological
processes, identifying and blocking the receptors by which thrombin activates platelets has …

Proteinase-activated receptors are a recently described, novel family of seven-
transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand …

Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying
receptor family and mediate many physiological processes, their role in tumor biology is …

Abstract Proteinase-activated receptors (PARs), a family of four seven-transmembrane G
protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs …

Protease-activated receptors 1–3 (PAR1, PAR2, and PAR3) are members of a unique G
protein-coupled receptor family. They are characterized by a tethered peptide ligand at the …

A DNA sequence encoding a G-protein-coupled receptor was isolated from a mouse
genomic library. The predicted protein is similar in structure to the thrombin receptor and has …