Global and regional prevalence of vitamin D deficiency in population-based studies from 2000 to 2022: A pooled analysis of 7.9 million participants

A Cui, T Zhang, P Xiao, Z Fan, H Wang… - Frontiers in Nutrition, 2023 - frontiersin.org
Background Vitamin D deficiency causes the bone hypomineralization disorder
osteomalacia in humans and is associated with many non-skeletal disorders. We aim to …

Vitamin D in the older population: a consensus statement

A Giustina, R Bouillon, B Dawson-Hughes, PR Ebeling… - Endocrine, 2023 - Springer
Background This paper reports results from the 5th International Conference “Controversies
in Vitamin D” that was held in Stresa, Italy, 15–18 September 2021. The conference is part of …

Vitamin D deficiency increases mortality risk in the UK Biobank: a nonlinear Mendelian randomization study

JP Sutherland, A Zhou, E Hyppönen - Annals of internal medicine, 2022 - acpjournals.org
Background: Low vitamin D status is associated with increased mortality, but randomized
trials on severely deficient participants are lacking. Objective: To assess genetic evidence …

Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial …

DA Jolliffe, H Holt, M Greenig, M Talaei, N Perdek… - bmj, 2022 - bmj.com
Objective To determine the effect of population level implementation of a test-and-treat
approach to correction of suboptimal vitamin D status (25-hydroxyvitamin D (25 (OH) D)< 75 …

The effects of exposure to solar radiation on human health

RE Neale, RM Lucas, SN Byrne, L Hollestein… - Photochemical & …, 2023 - Springer
This assessment by the Environmental Effects Assessment Panel (EEAP) of the Montreal
Protocol under the United Nations Environment Programme (UNEP) evaluates the effects of …

Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials

S Kuznia, A Zhu, T Akutsu, JE Buring… - Ageing research …, 2023 - Elsevier
To evaluate the effect of vitamin D 3 supplementation on cancer mortality in the general
population and on prognosis in cancer patients, a systematic review and meta-analysis of …

Critical appraisal of large vitamin D randomized controlled trials

S Pilz, C Trummer, V Theiler-Schwetz, MR Grübler… - Nutrients, 2022 - mdpi.com
As a consequence of epidemiological studies showing significant associations of vitamin D
deficiency with a variety of adverse extra-skeletal clinical outcomes including cardiovascular …

Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study

A Zhou, E Hyppönen - International Journal of Epidemiology, 2023 - academic.oup.com
Background Low vitamin D status is often associated with systemic low-grade inflammation
as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and …

Comparing the evidence from observational studies and randomized controlled trials for nonskeletal health effects of vitamin D

WB Grant, BJ Boucher, F Al Anouti, S Pilz - Nutrients, 2022 - mdpi.com
Although observational studies of health outcomes generally suggest beneficial effects with,
or following, higher serum 25-hydroxyvitamin D [25 (OH) D] concentrations, randomized …

Non-linear mendelian randomization: detection of biases using negative controls with a focus on BMI, vitamin D and ldl cholesterol

FW Hamilton, DA Hughes, W Spiller, K Tilling… - European Journal of …, 2024 - Springer
Mendelian randomisation (MR) is an established technique in epidemiological investigation,
using the principle of random allocation of genetic variants at conception to estimate the …