Defining the boundaries: challenges and advances in identifying cells in microscopy images
N Gogoberidze, BA Cimini - Current Opinion in Biotechnology, 2024 - Elsevier
Highlights•Adoption of segmentation models driven by user-friendly tools and
documentation.•Advancements in novel architectures are driven by the need for a truly …
documentation.•Advancements in novel architectures are driven by the need for a truly …
3D reconstruction of skin and spatial mapping of immune cell density, vascular distance and effects of sun exposure and aging
Mapping the human body at single cell resolution in three dimensions (3D) is important for
understanding cellular interactions in context of tissue and organ organization. 2D spatial …
understanding cellular interactions in context of tissue and organ organization. 2D spatial …
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration
A Guedán, CD Donaldson, ER Caroe… - PLoS …, 2021 - journals.plos.org
The capsid (CA) lattice of the HIV-1 core plays a key role during infection. From the moment
the core is released into the cytoplasm, it interacts with a range of cellular factors that …
the core is released into the cytoplasm, it interacts with a range of cellular factors that …
High-throughput image processing software for the study of nuclear architecture and gene expression
High-throughput imaging (HTI) generates complex imaging datasets from a large number of
experimental perturbations. Commercial HTI software programs for image analysis …
experimental perturbations. Commercial HTI software programs for image analysis …
[HTML][HTML] A spheroid whole mount drug testing pipeline with machine-learning based image analysis identifies cell-type specific differences in drug efficacy on a single …
M Vitacolonna, R Bruch, R Schneider, J Jabs… - BMC …, 2024 - pmc.ncbi.nlm.nih.gov
Background The growth and drug response of tumors are influenced by their stromal
composition, both in vivo and 3D-cell culture models. Cell-type inherent features as well as …
composition, both in vivo and 3D-cell culture models. Cell-type inherent features as well as …
[HTML][HTML] Brain-wide neuron quantification toolkit reveals strong sexual dimorphism in the evolution of fear memory
Fear responses are functionally adaptive behaviors that are strengthened as memories.
Indeed, detailed knowledge of the neural circuitry modulating fear memory could be the …
Indeed, detailed knowledge of the neural circuitry modulating fear memory could be the …
Nuclear instance segmentation and tracking for preimplantation mouse embryos
For investigations into fate specification and morphogenesis in time-lapse images of
preimplantation embryos, automated 3D instance segmentation and tracking of nuclei are …
preimplantation embryos, automated 3D instance segmentation and tracking of nuclei are …
[HTML][HTML] A novel ground truth dataset enables robust 3D nuclear instance segmentation in early mouse embryos
For investigations into fate specification and cell rearrangements in live images of
preimplantation embryos, automated and accurate 3D instance segmentation of nuclei is …
preimplantation embryos, automated and accurate 3D instance segmentation of nuclei is …
A comparison of microglial morphological complexity in adult mouse brain samples using 2-dimensional and 3-dimensional image analysis tools
CJ Murray, ED Tunderman, HA Vecchiarelli… - bioRxiv, 2024 - biorxiv.org
Characterizing cell morphology has been an essential aspect of neuroscience for over a
century to provide essential insights into cellular function and dysfunction. Microglia, the …
century to provide essential insights into cellular function and dysfunction. Microglia, the …
Developing a User-Friendly and Modular Framework for Deep Learning Methods in 3D Bioimage Segmentation
G Mougeot - 2023 - theses.hal.science
The emergence of deep learning has breathed new life into image analysis, especially for
the segmentation, a challenging step required to quantify bidimensional (2D) and …
the segmentation, a challenging step required to quantify bidimensional (2D) and …