Rho GTPases control signal transduction pathways that link cell surface receptors to a
variety of intracellular responses. They are best known as regulators of the actin …

The clearance of apoptotic cells by phagocytes is an integral component of normal life, and
defects in this process can have significant implications for self tolerance and autoimmunity …

Fishes moving through turbulent flows or in formation are regularly exposed to vortices.
Although animals living in fluid environments commonly capture energy from vortices …

Cytochrome P450 proteins (CYP450s) are membrane-associated haem proteins that
metabolize physiologically important compounds in many species of microorganisms, plants …

Mammalian Dock180 and ELMO proteins, and their homologues in Caenorhabditis elegans
and Drosophila melanogaster, function as critical upstream regulators of Rac during …

Phosphatidylserine recognition receptors are a highly diverse set of receptors grouped by
their ability to recognize the 'eat‐me'signal phosphatidylserine on apoptotic cells. Most of the …

The efficient elimination of apoptotic cells is crucial for tissue homeostasis in multicellular
organisms. Secreted" find-me," exposed" eat-me," and lacking" don't-eat-me" signals …

Mammalian DOCK180 protein and its orthologues Myoblast City (MBC) and CED-5 in
Drosophila and Caenorhabditis elegans, respectively, function as critical regulators of the …

The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end,
cells undergoing apoptosis must display engulfment signals, such as 'find-me'and 'eat …

Abstract The small GTPase Rac has a central role in regulating the actin cytoskeleton during
cell migration and axon guidance. Elmo has been identified as an upstream regulator of …