The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

Challenges in drug development of neurological diseases remain mainly ascribed to the
blood–brain barrier (BBB). Despite the valuable contribution of animal models to drug …

Atherosclerosis, which underlies life-threatening cardiovascular disorders such as
myocardial infarction and stroke, is initiated by passage of low-density lipoprotein (LDL) …

Macrophage autophagy is a highly anti-atherogenic process that promotes the catabolism of
cytosolic lipid droplets (LDs) to maintain cellular lipid homeostasis. Selective autophagy …

The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …

The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …

Rationale: Atherosclerosis is characterized by an accumulation of foam cells within the
arterial wall, resulting from excess cholesterol uptake and buildup of cytosolic lipid droplets …

Background: Atherosclerosis is driven by synergistic interactions between pathological,
biomechanical, inflammatory, and lipid metabolic factors. Our previous studies demonstrated …

Understanding the composition and function of the blood brain barrier (BBB) enables the
development of novel, innovative techniques for administering central nervous system …