[HTML][HTML] Emerging targeted therapies in advanced non-small-cell lung cancer

S Li, GS de Camargo Correia, J Wang, R Manochakian… - Cancers, 2023 - mdpi.com
Simple Summary The discovery of actionable oncogenic driver mutations in non-small-cell
lung cancer (NSCLC) has revolutionized the treatment and prognosis of this dreadful …

[HTML][HTML] Research progress and challenges in the treatment of central nervous system metastasis of non-small cell lung cancer

B Wang, H Guo, H Xu, H Yu, Y Chen, G Zhao - Cells, 2021 - mdpi.com
Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors and has
high morbidity and mortality rates. Central nervous system (CNS) metastasis is one of the …

[HTML][HTML] Experimental Study of Almonertinib Crossing the Blood-Brain Barrier in EGFR-Mutant NSCLC Brain Metastasis and Spinal Cord Metastasis Models

Y Zhang, Y Zhang, W Niu, X Ge, F Huang… - Frontiers in …, 2021 - frontiersin.org
Roughly one third of non-small cell lung cancer (NSCLC) patients with epidermal growth
factor receptor tyrosine kinase inhibitor (EGFR-TKI)-sensitive mutated (EGFRm) tumors …

[HTML][HTML] The role of targeted therapy and immune therapy in the management of non-small cell lung cancer brain metastases

C Billena, M Lobbous, CA Cordova… - Frontiers in …, 2023 - frontiersin.org
Brain metastases are a significant source of morbidity and mortality in patients with non-
small cell lung cancer. Historically, surgery and radiation therapy have been essential to …

[PDF][PDF] Sulforaphane overcomes T790M-mediated gefitinib resistance in vitro through epithelial-mesenchymal transition.

W Meng, J Meng, F Zhang, H Jiang, X Feng… - Journal of Physiology …, 2021 - jpp.krakow.pl
The purpose of the present study was to investigate the effects of sulforaphane (SFN) on
gefitinib-resistant cell lines with a T790 mutation (PC-9/AB11). The PC-9 and PC-9/AB11 …

Research Progress in the Treatment of Brain Metastases from Non-small Cell Lung Cancer.

HAN Xue, LI Hongmei - Chinese Journal of Lung Cancer, 2020 - search.ebscohost.com
Lung cancer is the leading cause of cancer-related deaths worldwide. The most common
pathological type of lung cancer is non-small cell lung cancer (NSCLC). The incidence of …

[HTML][HTML] A comparison between first-, second-and third-generation epidermal growth factor receptor tyrosine kinase inhibitors in patients with non-small-cell lung …

S Caponnetto, O Cantale, A Friedlaender… - Journal of Molecular …, 2021 - mdpi.com
Patients with non-small-cell lung cancer (NSCLC), harboring Epidermal Growth Factor
Receptor (EGFR) mutations, are more susceptible to brain metastases (BM). Comparisons of …

[HTML][HTML] Predictive effect of DCE-MRI and DWI in brain metastases from NSCLC

C Ye, Q Lin, Z Jin, C Zheng, S Ma - Open Medicine, 2021 - degruyter.com
Non-small cell lung cancer (NSCLC), a commonly diagnosed lung cancer, is characterized
by a high incidence of metastatic spread to the brain, which adversely impacts prognosis …

Primary lesion radiotherapy during first-line icotinib treatment in EGFR-mutated NSCLC patients with multiple metastases and no brain metastases: a single-center …

R Deng, J Liu, T Song, T Xu, Y Li, L Duo… - Strahlentherapie und …, 2022 - Springer
Background The most frequent mode of progression in the majority of non-small cell lung
cancer (NSCLC) patients treated with Epidermal growth factor–receptor tyrosine kinase …

[HTML][HTML] A meta-analysis for the efficacy and safety of icotinib combined with radiotherapy in treating brain metastases of non-small cell lung cancer

B Zhang - Medicine, 2023 - journals.lww.com
Background: Currently, the therapies for brain metastases of non-small cell lung cancer
(NSCLC) mainly include whole brain radiotherapy and icotinib. For exploring the efficacy …