Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and
peptides/proteins are an inevitable component of the aging process in all eukaryotic …

Forkhead box O (FOXO) proteins are a family of transcription factors with four members in
mammals, namely FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO factors, originally identified …

Caenorhabditis elegans (C. elegans) is a free-living nematode that has been extensively
utilized as an animal model for research involving aging and neurodegenerative diseases …

The biomechanical properties of extracellular matrices (ECM) and their consequences for
cellular homeostasis have recently emerged as a driver of aging. Here we review the age …

Retrograded starch is known to be resistant to digestion. We used enzyme kinetic
experiments to examine how retrogradation of starch affects amylolysis catalysed by porcine …

Aging is a process characterized by accumulating degenerative damages, resulting in the
death of an organism ultimately. The main goal of aging research is to develop therapies …

Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …

Ageing is a major risk factor for many conditions including cancer, cardiovascular and
neurodegenerative diseases. Pharmaceutical interventions that slow down ageing and …

There is growing interest in pharmacological interventions directly targeting the aging
process. Pharmacological interventions against aging should be efficacious when started in …

Over the past decades, Caenorhabditis elegans (C. elegans) has been widely used as a
model system because of its small size, transparent body, short generation time and lifespan …